PROGRESS

Our Performace .

2019

Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, Kumaki S, Miyazaki Y, Motohashi H, Yamamoto M, Tanaka N. 

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.

J Immunol. 2019 Mar 1;202(5):1331-1339. doi: 10.4049/jimmunol.1801180.

2018

Tsukita Y, Okazaki T, Ebihara S, Komatsu R, Nihei M, Kobayashi M, Hirano T, Sugiura H, Tamada T, Tanaka N, Sato Y, Yagita H, Ichinose M. 

Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5.

Oncoimmunology. 2018 Nov 13;8(2):e1543526. doi: 10.1080/2162402X.2018.1543526.

Suga J, Izumiyama K, Tanaka N, Saji S. 

Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7.

Biochem Biophys Rep. 2018 Oct 26;16:103-109. doi: 10.1016/j.bbrep.2018.10.008

 

2017

Sato T, Morita M, Tanaka R, Inoue U, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N,  Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y and Tanuma N

Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.

Oncologist Letters 2017 14(6): 6863–6868. doi: 10.3892/ol.2017.7098.

Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.

“Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.” 

Cancer Science 108:435-443 (2017) doi: 10.1111/cas.13163.12, 61.

Willén K, Edgar JR, Hasegawa T, Tanaka N, Futter CE, Gouras GK.

“Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.” 

Molecular Neurodegeneration 12, 61 (2017) doi: 10.1186/s13024-017-0203-y. 

Sato T, Morita M, Tanaka R, Inoue Y,  Nomura M, Sakamoto Y, Miura K, Ito S, Sato I,  Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y, Tanuma N.

“Ex vivo model of non‑small cell lung cancer using mouse lung epithelial cells” 

Oncology Letters 14, 6863-6868 (2017) doi: https://doi.org/10.3892/ol.2017.7098. 

2016

Oshima R, Hasegawa T, Tamai K, Sugeno N, Yoshida S, Kobayashi J, Kikuchi A, Baba T, Futatsugi A, Sato I, Satoh K, Takeda A, Aoki M & Tanaka N 

“ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways” 

Scientific Reports 6, 24997 (2016) doi:10.1038/srep24997 

 

Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. 

“EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method”

Can Respir J. 2016;2016:5297329. doi: 10.1155/2016/5297329.

 

Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. 

“Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription”

Nature Communications. 2016 7:11624. doi: 10.1038/ncomms11624.

 

Mochizuki M. Tamai K. Imai T. Sugawara S. Ogama N. Nakamura M. Matsuura K. Yamaguchi K. Satoh K. Sato I. Motohashi H. Sugamura, K. & Tanaka, N.

“CD271 regulates the proliferation and motility of hypopharyngeal cancer cells”

Scientific Reports 6, Article number: 30707. (2016) doi: 10.1038/srep30707 

 

Maejima R, Tamai K, Shiroki T, Yokoyama M, Shibuya R, Nakamura M, Yamaguchi K, Abue M, Oikawa T, Noguchi T, Miura K, Fujiya T, Sato I, Iijima K, Shimosegawa T, Tanaka N, Satoh K. 

“Enhanced expression of semaphorin 3E is involved in the gastric cancer development”

Int J Oncol. 2016;49:887-94. doi: 10.3892/ijo.2016.3593.

 

Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, Ine S, Sasaki O, Satoh K, Tanaka N, Harigae H. & Sugamura K.

“Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation”

Cancer Science. 107, 638-643, 2016. doi: 10.1111/cas.12921.

 

Mizuguchi M, Sasaki Y, Hara T, Higuchi M, Tanaka Y, Funato N, Tanaka N, Fujii M, Nakamura M.

“Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax”

PLoS One, 11:e0148217(2016).

 

2014

Nagata T, Murata K, Murata R, Sun SL, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K & Ishii N.

“Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells”.

Biochem Biophys Res Commun. 2014;443:351-6. doi: 10.1016/j.bbrc.2013.11.029.

 

Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K & Tanaka N. “Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma” 

Cancer Science 105, 667-674 (2014)

 

Watanuki Z, Kosai H, Osanai N, Ogama N, Mochizuki M, Tamai K, Yamaguchi K, Satoh K, Fukuhara T, Maemondo M, Ichinose M, Nukiwa T, Tanaka N

“Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling” 

Biochem Biophy Res Commun. 455, 269-276 (2014)

Publications

Grants

2019   科研費 基盤研究(C)​           代表 小鎌 直子

2019   科研費 若手(B)​                 代表   長島 隆一

2018   科研費 基盤研究(B)​           代表 田中 伸幸

2018   科研費 若手(B)​                 代表   西川路武人

2018   東北大学加齢医学研究所共同研究 田中 伸幸

2017   JST-CREST 細胞外微粒子に起因する生命現象の解明とその制御に向けた基盤技術の創出 福田チーム   

                   分担 田中 伸幸

2017   内藤記念科学奨励金・研究助成    田中 伸幸

2017   東北大学加齢医学研究所共同研究 田中 伸幸

2017   科研費 若手(B)​              代表 長島 隆一

2016   科研費 若手(B)​                代表   泉山 慶子

2015   科研費 若手(B)​                代表   小齋 仁美

2015   科研費 挑戦的萌芽        代表 田中 伸幸

2013   科研費 基盤研究(B)          代表 田中 伸幸

2011   JST-CREST 慢性炎症         分担   田中 伸幸

Awards

2017   北里医学会賞             長島 隆一

2017   北斗医学賞           西川路 武人

2014   東北大学大学院博士課程ブースター 大嶋 龍司

東北大学 医学系研究科 がん病態学分野

© 2017 Tumor Immunobiology

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